Inter vs Shakhtar Donetsk: Prediction, H2H & Betting Tips

Inter take on Shakhtar Donetsk in the UEFA Champions League on Wednesday, 21 October 2026 at Stadio Giuseppe Meazza. Below is our data-driven preview and prediction for this fixture, based on head-to-head history, recent form and league position.

Going into the game, Inter sit 32nd in the UEFA Champions League on 0 points from 2 games, while Shakhtar Donetsk are 15th on 4 points.

Final result: Inter 1–0 Shakhtar Donetsk. Inter won the match.

Inter come into this fixture having won 3, drawn 1 and lost 1 of their last 5 games (DWLWW), scoring in every game.

Shakhtar Donetsk come into this fixture having won 1, drawn 1 and lost 1 of their last 3 games (DWL), scoring in 2 of them.

In their last 6 meetings, Inter have won 2, drawn 3 and lost 0 against Shakhtar Donetsk. These fixtures have averaged 1.2 goals per game, with both teams scoring in 0% of them.

Defensively, Inter kept 5 clean sheets and Shakhtar Donetsk kept 3 across those meetings, giving a useful guide to how tight this matchup tends to be.

Our prediction for Inter vs Shakhtar Donetsk is Home Win to Nil No with a 66% confidence rating at odds of 1.5. This tip is informed by the head-to-head trends above (1.2 goals per game, 0% both-teams-to-score), recent form (Inter DWLWW, Shakhtar Donetsk DWL), the 17-place gap between the sides in the table.