1899 Hoffenheim vs Lyon: Prediction, H2H & Betting Tips

1899 Hoffenheim take on Lyon in the UEFA Europa League on Thursday, 22 October 2026 at PreZero Arena. Below is our data-driven preview and prediction for this fixture, based on head-to-head history, recent form and league position.

Going into the game, 1899 Hoffenheim sit 30th in the UEFA Europa League on 0 points from 1 game, while Lyon are 3rd on 6 points.

1899 Hoffenheim come into this fixture having won 1, drawn 0 and lost 4 of their last 5 games (LLLLW), scoring in 4 of them.

Lyon come into this fixture having won 4, drawn 0 and lost 1 of their last 5 games (WWLWW), scoring in every game.

In their last 4 meetings, 1899 Hoffenheim have won 0, drawn 3 and lost 0 against Lyon. These fixtures have averaged 3.5 goals per game, with both teams scoring in 75% of them.

Defensively, 1899 Hoffenheim kept 0 clean sheets and Lyon kept 0 across those meetings, giving a useful guide to how tight this matchup tends to be.

Our prediction for 1899 Hoffenheim vs Lyon is Away or over 2 goals with a 87% confidence rating at odds of 1.15. This tip is informed by the head-to-head trends above (3.5 goals per game, 75% both-teams-to-score), recent form (1899 Hoffenheim LLLLW, Lyon WWLWW), the 27-place gap between the sides in the table.